Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 70, Pages 10191-10194Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04855k
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Funding
- National Natural Science Foundation of China [21735003, 21527811, 21605096, 21974080]
- Award for Team Leader Program of Taishan Scholars of Shandong Province, China
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We demonstrate for the first time the construction of a low background electrochemical biosensor with tandem signal amplification for sensitive microRNA assay based on target-activated catalytic hairpin assembly (CHA) of heteroduplex-templated copper nanoparticles. This electrochemical biosensor exhibits high sensitivity, good specificity, single-base mismatch discrimination capability, excellent stability and reproducibility, and it can sensitively detect microRNA in cancer cells.
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