Journal
DRUG DELIVERY
Volume 27, Issue 1, Pages 1271-1282Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2020.1809557
Keywords
Antibiotic resistance; gold nanoparticle; pH-sensitive drug delivery; Serratia marcescens
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Funding
- DST-SERB, Government of India under the scheme of 'EMEQ' New Delhi [SB/EMEQ-241-2014]
- UGC under UPE programs
- King Saud University, Riyadh, Saudi Arabia [RSP-2020/110]
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Antibiotic resistance amongst microbial pathogens is a mounting serious issue in researchers and physicians. Various alternatives to overcome the multidrug-resistant bacterial infections are under search, and biofilm growth inhibition is one of them. In this investigation, a polymeric drug delivery system loaded with multi-serratial drugs to improve the delivery of drugs against urinary tract infection causativeSerratia marcescens. The chitosan grafted pyromellitic dianhydride - cysteine (CS-g-PMDA-CYS) was conjugated with AuNPs by using the -SH group of CYS and RF (rifampicin) and INH (isoniazid) were loaded in AuNPs-fused CS-g-PMDA-CYS system. Several physicochemical techniques characterized this fabricated AuNPs/RF/INH/CS-g-PMDA-CYS system. The successful encapsulation of RF and INH in AuNPs-fused CS-g-PMDA-CYS polymer had confirmed, and it observed the loading capacity for RF and INH was 9.02% and 13.12%, respectively. Thein vitrodrug discharge pattern was perceived high in pH 5.5 compared with pH 7.4. The AuNPs/RF/INH/CS-g-PMDA-CYS escalates 74% ofCaenorhabditis eleganssurvival duringSerratia marcescensinfection by aiming biofilm development and virulence inS. marcescens. Author postulate that the fabricated system is a promising drug carrier and delivery system for inhibition of multidrug-resistant bacterias likeS. marcescens.
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