Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 34, Pages 7792-7800Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00186d
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Funding
- National Key Research and Development Program of China [2017YFE0131700]
- National Natural Science Foundation of China [21874096, 21575095]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- 111 Project
- Joint International Research Laboratory of Carbon-Based Functional Materials and Devices
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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There is increasing demand for anti-doping drug monitoring in sports and food safety checks by developing sensitive and fast analytical methods. Here we report the development of hybrid Ir/SiNW as a new MALDI matrix for the detection of small molecules. This matrix is characterized by sufficient UV absorption, low-noise background, and high efficiency in ionization of small molecules. Sensitive detection of clenbuterol (LOD: 0.18 pmol) and a variety of other small molecules has been achieved using the Ir/SiNW matrix with a reproducible performance. Compared to the individual components separately, the matrix of hybrid Ir/SiNW synthesizedvia in situgrowth can promote the MS signal intensity by up to 10 fold under identical experimental conditions. We provide a unique mechanism for the high performance of the hybrid Ir/SiNW matrix with the characteristic properties of hydrogen atom transfer and enhanced protonation at the interface of the hybrid nanostructures. Our approach of using a hybrid Ir/SiNW matrix enables detection of clenbuterol quantitatively in complicated biological samples andin vivoexperiments, promising a useful tool for food security and anti-doping drug monitoring in sports.
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