Journal
INHALATION TOXICOLOGY
Volume 29, Issue 8, Pages 374-385Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08958378.2017.1385661
Keywords
Allethrin; mosquito coils; spermatogenesis; acrosome reaction; antioxidants; oxidative stress
Categories
Funding
- University Grants Commission
- Council for Scientific and Industrial Research, Government of India
Ask authors/readers for more resources
The threat of zika virus looms throughout the world and the use of allethrin-based mosquito coils to prevent mosquito bites during and postpregnancy is on the rise. The aim of this study was to analyze the toxic effects of exposure to allethrin-based mosquito coil smoke in rats under conditions that reflect human settings. Pregnant female rats were exposed to mosquito coil smoke and same was continued to the male pups up to 111days postparturition (21-day weaning plus up to 90days postweaning). Increased oxidative stress, distorted antioxidant enzyme status, downregulation of genes involved in spermatogenesis, sperm maturation and steroidogenesis was observed. Daily sperm production, total sperm count and acrosome reaction was compromised. Results of our study indicate the toxic effects of exposure to allethrin-based mosquito coil smoke in male offspring and calls for preventing mosquito coil use during pregnancy and postnatal development. Community-based programs that will encourage general population to use classical methods such as use of mosquito nets, keeping the surroundings clean and use of natural mosquito repellents should be conducted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available