4.6 Article

Iridium-catalyzed enantioselective reductive amination of aromatic ketones

Journal

CATALYSIS SCIENCE & TECHNOLOGY
Volume 10, Issue 16, Pages 5448-5452

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cy01271h

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Funding

  1. Key R&D Program in Shaanxi Province of China [2020SF-202]
  2. Natural Science Basic Research Plan in Shaanxi Province of China [2020JZ-26]
  3. Fourth Military Medical University [2018XA009]

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A highly efficient direct asymmetric reductive amination of aromatic ketones catalyzed by an iridium complex of Josiphos-type binaphane ligands was described. This concise and practical method provided chiral amines in high yields and enantioselectivities (up to 99% ee).

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