Journal
PHYSICAL REVIEW E
Volume 102, Issue 2, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.102.020601
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Funding
- European Unions Horizon 2020 research and innovation programme under the Marie SklodowskaCurie Grant [722497 LubISS]
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Collective chemotaxis plays a key role in the navigation of cell clusters in, e.g., embryogenesis and cancer metastasis. Using the active nematic continuum equations, coupled to a chemical field that regulates activity, we demonstrate and explain a physical mechanism that results in collective chemotaxis. The activity naturally leads to cell polarization at the cluster interface which induces outward flows. The chemical gradient then breaks the symmetry of the flow field, leading to a net motion. The velocity is independent of the cluster size, in agreement with experiment.
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