Journal
BIOMATERIALS
Volume 258, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120257
Keywords
Layered double hydroxides; Fenton reaction; Chemodynamic therapy; Cancer theranostic
Funding
- National Natural Science Foundation of China [NSFC: 21521005, 21971007, 21671013, 21601010]
- Fundamental Research Funds for the Central Universities [buctylkxj01, XK1802-6, XK1803-05]
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Currently, reactive oxygen species (ROS)-induced apoptosis systems have drawn increasing attention in cancer therapy, owing to their specific tumor inhibition ability and great biocompatibility. Herein, we developed a highly dispersed nano-enzyme based on the assembly of natural glucose oxidase (GOD) onto CoFe-layered double hydroxides (CoFe-LDHs) monolayer nanosheets. By virtue of the high dispersion of Fe3+ within the host layer, the CoFe-LDHs nanosheets exhibit a collaborative enhanced Fenton catalytic activity with a rate constant of 3.26 x 10(-4) s-(1) , which is 1-3 orders of magnitude higher than other iron-containing Fenton reaction agents. Subsequently, with a massive H2O2 triggered by GOD, GOD/CoFe-LDHs nanohybrid converts a cascade of glucose into hydroxyl radicals under tumor acid conditions, which is validated by a high maximum velocity (V-max = 2.23 x 10(-6) M) and low Michaelis-Menten constant (K-M = 5.40 mM). Through the intracellular catalytic Fenton reaction within the tumor environment, both in vitro and in vivo results demonstrate the excellent antitumor effect of GOD/CoFe-LDHs. Therefore, a self-supplied, ultra-efficient and sequential catalytic tumor-specific therapy has been achieved based on GOD/CoFe-LDHs nano-enzyme, which holds great promise in clinical cancer therapy with minimum side effects.
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