Journal
APPLIED RADIATION AND ISOTOPES
Volume 165, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2020.109341
Keywords
(CuCl2)-Cu-64; No-carrier-added; PET; Radiochemical separation; Radiopharmaceuticals; Research reactor; Theranostics
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Funding
- International Atomic Energy Agency - Coordinated Research Project (IAEA-CRP) [F22067]
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Copper-64 is an excellent theranostic radiometal that is gaining renewed attention of the clinical community in the recent times. In order to meet the increasing demand of this radiometal, we have demonstrated the viability of its production via Zn-64 (n,p) Cu-64 reaction in a nuclear reactor. A semi-automated radiochemical separation module based on selective extraction of Cu-64 as dithizonate complex was developed. The maximum available activity at the end of irradiation was similar to 700 MBq. The overall yield of Cu-64 after the separation process was >85% and it could be obtained with similar to 12 GBq/mu g specific activity, >99.9% radionuclidic purity and >98% radiochemical purity. The separated Cu-64 could be utilized for preparation of a wide variety of radiopharmaceuticals.
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