Efficacy of Periodontal Tissue Regeneration Combined with Orthodontic Therapy on Periodontitis and Its Influences on Inflammatory Factors in Patients

Objective: To assess the effect of periodontal tissue regeneration combined with orthodontic treatment on periodontitis and inflammatory factors. Methods: 100 patients with periodontitis were randomly separated into observation group and control group. Patients were treated with periodontal tissue regeneration in control group and received orthodontic treatment in observation group. The periodontal indexes, X-ray cephalometric indexes, serum inflammatory factor levels, tooth mobility, the postoperative complications, efficacy and life quality were measured. Results: After treatment, levels of clinical attachment loss (CAL), probing depth (PD), sulcus bleeding index (SBI), gingival index (GI), plaque index (PLI), SNB angle, SNA angle, IL-8, IL-5, TNF-alpha and hs-CRP of patients in observation group were significantly decreased, while ANB angle was significantly elevated (p < 0.05). Meanwhile, the treatment effective rate and quality of life score was significantly improved after treatment in observation group (p < 0.05). Conclusion: Periodontal tissue regeneration combined with orthodontic treatment can significantly improve periodontitis symptoms, promote the recovery of tooth function, reduce inflammation and postoperative complications, and improve the uniformity and appearance of teeth in patients with periodontitis.