Journal
INFLAMMATION
Volume 40, Issue 4, Pages 1123-1130Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-017-0556-y
Keywords
GSK3 beta; Wnt signaling pathway; DKK1; NaF; neuroinflammation
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Funding
- Natural Science Foundation of Jiangsu Province, China [BK20151159]
- National Natural Science Foundation of China [81501185]
- Jiangsu Provincial Medical Youth Talent [QNRC2016369]
- Xuzhou Medical Talents Project
- Xuzhou technological and scientific project [KC14SH050]
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Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3 beta is a key protein that modulates NF-kappa B activity and inflammatory cytokine levels and plays an important role in the Wnt signaling pathway. In this study, we found that fluoride altered the inflammatory status and oxidative stress by inhibiting Wnt signaling pathway activity. This study thus provides a valid basis for the fluorine-induced neuroinflammation injury theory.
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