Journal
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
Volume 31, Issue 4, Pages 593-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2017.07.017
Keywords
Older adults; Immunosenescence; Frailty; Thermoregulation; Malnutrition
Categories
Funding
- AstraZeneca
- Merck
- Pfizer [13162823]
- Steris
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI100560, R01AI063517, R21AI114508, R01AI072219]
- Cleveland Department of Veterans Affairs
- Geriatric Research Education and Clinical Center
- VA Office of Research and Development [1I01BX001974, PPO 16-118-1]
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In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age-related organ-specific physiologic changes, and frailty. We also describe clinical factors influencing infection risk and presentation in older adults, including temperature regulation, cognitive decline, and malnutrition. Finally, we discuss the influence of the setting in which older adults reside on the clinical evaluation of infection. Understanding the influence of all these changes may facilitate the prevention, early recognition, and treatment of infections in older adults.
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