Journal
INFECTION GENETICS AND EVOLUTION
Volume 54, Issue -, Pages 54-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2017.06.013
Keywords
Feline calicivirus; Open reading frame 2 (ORF2); Codon usage; Mutation pressure; Natural selection; Neutrality analysis
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Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Feline calicivirus (FCV) is a highly prevalent pathogen of the domestic cat that causes acute infections of the oral and upper respiratory tract. The E region of the ORF2 protein is responsible for the induction of virus-neutralizing antibodies, thus it is important to understand the codon usage of this gene. Here, analysed 90 coding sequences of ORF2 and show that it undergoes a low codon usage bias. In addition, although mutational bias is one of the factors shaping the codon usage bias of this gene, natural selection plays a more significant role. Our results reveal part of the mechanisms driving FCV evolution, which will lay foundation for the further research of FCV. (C) 2017 Elsevier B.V. All rights reserved.
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