Journal
INFECTION GENETICS AND EVOLUTION
Volume 49, Issue -, Pages 174-185Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2016.12.022
Keywords
Alphaherpesvirus; Natural recombination; Next-generation sequencing; Attenuated live vaccine
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Funding
- Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), Chilean Government
- Australian Research Council [FT140101287]
- Australian Research Council [FT140101287] Funding Source: Australian Research Council
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Recombination in alphaherpesviruses was first described more than sixty years ago. Since then, different techniques have been used to detect recombination in natural (field) and experimental settings. Over the last ten years, next-generation sequencing (NGS) technologies and bioinformatic analyses have greatly increased the accuracy of recombination detection, particularly in field settings, thus contributing greatly to the study of natural alphaherpesvirus recombination in both human and veterinarymedicine. Such studies have highlighted the important role that natural recombination plays in the evolution of many alphaherpesviruses. These studies have also shown that recombination can be a safety concern for attenuated alphaherpesvirus vaccines, particularly in veterinary medicine where such vaccines are used extensively, but also potentially in human medicine where attenuated varicella zoster virus vaccines are in use. This review focuses on the contributions that NGS and sequence analysis have made over the last ten years to our understanding of recombination in mammalian and avian alphaherpesviruses, with particular focus on attenuated live vaccine use. (C) 2016 Elsevier B.V. All rights reserved.
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