Journal
MATHEMATICAL BIOSCIENCES AND ENGINEERING
Volume 17, Issue 4, Pages 2853-2861Publisher
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/mbe.2020159
Keywords
SARS-CoV-2; MERS; di fferential equation model; basic reproductive number
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Funding
- National Natural Science Foundation of China [11701445]
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JQ1057]
- Young Talent Fund of University Association for Science and Technology in Shaanxi, China [20180504]
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In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model.
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