Journal
CURRENT DEVELOPMENTS IN NUTRITION
Volume 4, Issue 1, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1093/cdn/nzz102
Keywords
blood pressure; hypertension; hypertension in pregnancy; one-carbon metabolism; MTHFR; folate; riboflavin; single nucleotide polymorphism; gene-nutrient interaction; personalized nutrition
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Funding
- Irish Department of Agriculture, Food and the Marine
- Health Research Board (under the Food Institutional Research Measure initiative)
- Northern Ireland Department for Employment and Learning
- DSM Nutritional Products
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Hypertension in adulthood is recognized as the leading risk factor contributing to mortality worldwide, primarily from cardiovascular disease, whereas hypertension in pregnancy leads to serious adverse fetal and maternal outcomes. This article explores the under-recognized role of one-carbon metabolism in blood pressure (BP) and the potential for folate-related B vitamins to protect against hypertension. Genome-wide association studies and clinical studies provide evidence linking the 677C -> T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with BP and increased risk of hypertension and hypertension in pregnancy. A novel role for riboflavin (the MTHFR cofactor) has recently emerged, however, with evidence from randomized trials that supplemental riboflavin can lower BP specifically in adults with the variant MTHFR 677TT genotype. Further studies are required to elucidate the biological mechanisms linking one-carbon metabolism with BP and explore the effect of riboflavin in modulating the genetic risk of hypertension in early and later life.
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