Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 77, Pages 11461-11464Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04875e
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Funding
- National Natural Science Foundation of China [81773562, 81973177, 81703326]
- China Postdoctoral Science Foundation [2018M630840, 2019T120641]
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Pseudo natural products (NPs) feature structural novelty and diversity and thus are a new source of lead compounds for drug discovery. We first report the mesoporous silica nanoparticles (MSNs)-catalyzed de novo combination of benzodiazepine and isoindolinone, giving tetracyclic benzodiazepine-fused isoindolinone pseudo natural products (21 examples, 55-91% yields). The work also demonstrates that MSNs are efficient acidic catalysts for multi-component reactions.
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