Journal
JOURNAL OF EXTRACELLULAR VESICLES
Volume 9, Issue 1, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/20013078.2020.1816641
Keywords
Calibration; exosomes; extracellular vesicles; microvesicles; optical analysis; reference materials; standardization; quality control; validation
Categories
Funding
- U.S. National Institutes of Health, National Cancer Institute [1ZIA-BC011502]
- Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute, Center for Cancer Research
- NIH [ZIA BC011502, ZIA BC011503, U01 HL126497, R01 CA218500, UG3 TR002881, DA040385, DA047807, AI144997, MH118164, UG3CA241694]
- FNIH Ruth Anne Cafritz Award
- Prostate Cancer Foundation YIA funding
- Michael J. Fox Foundation
- Slovenian Research Agency (ARRS) [P1-0170, J3-9255]
- Norwegian Research Council
- South-Eastern Norway Regional Health Authority
- Netherlands Organisation for Scientific Research-Domain Applied and Engineering Sciences (NWO-TTW) [VENI 15924]
- European Metrology Research Programme Joint Research Project [18HLT01: METVES II]
- BBSRC [BB/P006205/1]
- Cancer Research UK [A28052]
- Biotechnology and Biological Sciences Research Council [BB/P006205/1]
- European Metrology Programme for Innovation and Research [18HLT01]
- Michael J. Fox Foundation for Parkinson's Research
- National Cancer Institute [1ZIA-BC011502, U01 HL126497, R01 CA218500, UG3 TR002881]
- National Department of Health [ZIA BC011502, ZIA BC011503]
- National Institutes of Health [DA040385, DA047807, AI144997, MH118164, UG3CA241694]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NL) [VENI 15924]
- South- Eastern Norway Regional Health Authority
- Slovenian Research Agency [J3-9255, P10170]
- Prostate Cancer Foundation
- BBSRC [BB/P006205/1] Funding Source: UKRI
Ask authors/readers for more resources
Accurate characterization of extracellular vesicles (EVs) is critical to explore their diagnostic and therapeutic applications. As the EV research field has developed, so too have the techniques used to characterize them. The development of reference materials are required for the standardization of these techniques. This work, initiated from the ISEV 2017 Biomarker Workshop in Birmingham, UK, and with further discussion during the ISEV 2019 Standardization Workshop in Ghent, Belgium, sets out to elucidate which reference materials are required and which are currently available to standardize commonly used analysis platforms for characterizing EV refractive index, epitope abundance, size and concentration. Due to their predominant use among EV researchers, a particular focus is placed on the optical methods nanoparticle tracking analysis and flow cytometry.
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