Journal
NEURODEGENERATIVE DISEASE MANAGEMENT
Volume 10, Issue 6, Pages 357-367Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nmt-2020-0039
Keywords
activities of daily living; Alzheimer's disease; dementia with Lewy bodies; functional decline; hippocampal subfields
Categories
Funding
- Norwegian government
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
- King's College London
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Background: Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials & methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Conclusion: Functional decline does not depend on HSv in mild AD and DLB.
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