Journal
CUREUS JOURNAL OF MEDICAL SCIENCE
Volume 12, Issue 9, Pages -Publisher
SPRINGERNATURE
DOI: 10.7759/cureus.10583
Keywords
neuroimaging; propofol infusion syndrome; anoxic injury; hypoxic injury; encephalopathy; pediatrics
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A school-age boy with a complex medical history underwent a minor elective surgical procedure. Propofol was used for sedation during the procedure. The patient could not be awakened post-operatively. Laboratory findings demonstrated metabolic lactic acidosis, leukocytosis with bandemia, and transaminitis. Neuroimaging demonstrated findings that were consistent with hypoxic-ischemic or toxic-metabolic brain injury involving the bilateral basal ganglia, hippocampi, and cerebellum. The patient's condition progressively worsened over the course of the following few weeks, and brain death was confirmed by scintigraphy seven weeks later. Prompt neuroimaging in unresponsive patients with suspected propofol infusion syndrome (PIUS) is of critical importance in detecting neurologic injuries, excluding alternative diagnoses, and determining prognostication.
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