Journal
BIOTECHNOLOGY ADVANCES
Volume 43, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2020.107551
Keywords
Filamentous fungi; metabolic engineering; primary metabolism; TCA cycle; Pentose catabolic pathway; D-galacturonic acid pathway; glycolysis; organic acids; genome-scale models
Categories
Funding
- Academy of Finland [308284]
- Academy of Finland (AKA) [308284, 308284] Funding Source: Academy of Finland (AKA)
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Filamentous fungi are important industrial cell factories used for the production of a wide range of enzymes and metabolites. Their primary metabolism is a significant source of industrially important compounds, as well as of monomeric building blocks for the production of secondary metabolites and extracellular enzymes. Therefore, large efforts have been made towards the development of suitable strains for the industrial scale production of primary metabolites. Over the last decades, metabolic engineering of primary metabolism has become a powerful tool to enhance production of both primary and secondary metabolites. This review summarises the different metabolic engineering methods that have been applied to rationally improve the production of industrially relevant primary metabolites in filamentous fungi, and discusses related challenges and future perspectives.
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