Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 35, Pages 6881-6888Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01504k
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Funding
- Natural Science Foundation of Shandong Province [ZR2018BB026]
- Doctoral Start-Up Scientific Research Foundation of Qufu Normal University
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A methylenation-cyclization reaction, employing cyclic enaminones with primary aromatic amines and two molecules of CO2, furnishing fused-tetrahydropyrimidines, is discussed. In this Cs(2)CO(3)and ZnI(2)catalyzed one-pot two-step procedure, two molecules of CO(2)were selectively converted to methylene groups. The multi-component reaction might proceed through the formation of bis(silyl)acetal which was followed by condensation and further aza-Diels-Alder reaction. Hydroquinazoline, hydrocyclopenta[d]pyrimidine and hydroindeno[1,2-d]pyrimidine derivatives could be prepared with CO(2)as the C1 source, effectively.
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