Journal
FOOD & FUNCTION
Volume 11, Issue 9, Pages 8354-8368Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo01575j
Keywords
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Funding
- National Key RAMP
- D Program of China [2018YFD0400905]
- National Natural Science Foundation of China [31871833]
- Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences [CAAS-ASTIP-2020-IFST-04]
- Central Public-interest Scientific Institution Basal Research Fund [S2020JBKY-18]
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Recently, we have proposed that quinoa yoghurt (QY) has the anti-diabetic properties based on anin vitrostudy. Here, its antidiabetic activity was further validated by investigating its hypoglycemic and hypolipidemic influence in high fat diet/streptozotocin-induced type 2 diabetes mellitus (T2DM) mice. The results showed that QY increased the body weights of and reduced the fasting blood glucose levels in T2DM mice. QY significantly (p< 0.05) reduced the serum levels of total cholesterol, triglyceride and LDL-C, while it increased the HDL-C level. In addition, the hepatic glycogen content, and superoxide dismutase, catalase, and glutathione peroxidase activities were significantly (p< 0.05) increased, while lipid peroxidation was remarkably reduced. Sprouted QY had the highest influence on serum oxidation when compared with non-germinated QY. The level of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1 beta) were significantly (p< 0.05) decreased, while the level of anti-inflammatory cytokine IL-10 was increased. Histopathological studies showed that QY protected the tissue structure of the liver of T2DM mice. Immunohistochemistry showed that QY increased AKT-2 and AMPK-alpha 2 expressions, while it suppressed p85. The qRT-PCR analysis indicated that QY exerted its hypoglycemic and anti-hyperlipidemic effects through the AKT/AMPK/PI3K signaling pathway. Germination significantly (p< 0.05) influenced the glucose and lipid homeostasis in T2DM mice in such a way that sprouted QY showed the highest hypoglycemic and cholesterol-lowering effects when compared with non-germinated QY.
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