Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 56, Issue 20, Pages 5761-5777Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.iecr.7b00990
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Funding
- National Science Foundation [DMR 1255281]
- National Institutes of Health [NIH/R21CA191740]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1255281] Funding Source: National Science Foundation
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Many diseases can be characterized by the abnormal activity exhibited by various biomolecules, the targeting of which can provide therapeutic and diagnostic utility. Recent trends in medicine and nanotechnology have prompted the development of protease sensitive nanomaterials systems for therapeutic, diagnostic, and theranostic applications. These systems can act specifically in response to the target enzyme and its associated disease conditions, thus enabling personalized treatment and improved prognosis. In this Review, we discuss recent advancements in the development of protease-responsive materials for imaging and drug delivery and analyze several representative systems to illustrate their key design principles.
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