Journal
INDIAN PEDIATRICS
Volume 54, Issue 1, Pages 49-50Publisher
SPRINGER INDIA
DOI: 10.1007/s13312-017-0996-3
Keywords
Cyclosporine; Focal segmental glomerulosclerosis; Treatment failure
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A recent randomized control trial in children with steroid-resistant nephrotic syndrome revealed that two doses of rituximab did not reduce proteinuria. A 14-month-old boy developed refractory steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis. The patient achieved complete remission 11 months after disease onset following eight doses of rituximab combined with steroids and cyclosporine. Long-lasting B cell depletion with repeated rituximab administrations may be required to achieve complete remission in patients with steroid-resistant nephrotic syndrome and massive proteinuria.
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