Journal
MATERIALS TODAY BIO
Volume 7, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtbio.2020.100068
Keywords
Secondary structure; Beta sheet; Adhesion; Rheology; Circular dichroism
Funding
- Defence Science Technology Laboratory (DSTL)
- SynbiCITE [DSTLX-1000012335, DSTLX1000101893]
- EPSRC/BBSRC Future Biomanufacturing Research Hub [EP/S01778X/1]
- BBSRC [BB/M017702/1] Funding Source: UKRI
- EPSRC [EP/P025021/1, EP/S01778X/1, EP/S019367/1] Funding Source: UKRI
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Protein-based adhesives could have several advantages over petroleum-derived alternatives, including substantially lower toxicity, smaller environmental footprint, and renewable sourcing. Here, we report that noncovalently crosslinked bovine serum albumin and recombinant spider silk proteins have high adhesive strength on glass (8.53 and 6.28 MPa, respectively) and other transparent substrates. Moreover, the adhesives have high visible transparency and showed no apparent degradation over a period of several months. The mechanism of adhesion was investigated and primarily attributed to dehydration-induced reorganization of protein secondary structure, resulting in the supramolecular association of beta-sheets into a densely hydrogen-bonded network.
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