Journal
MICROCHEMICAL JOURNAL
Volume 158, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.microc.2020.105191
Keywords
Viscosity; Xanthene-hemicyanine dye; Fluorescent probe; Cell imaging; Mitochondria
Categories
Funding
- National Natural Science Foundation of China [NNSFC 21907075, 21272172]
- Natural Science Foundation of Tianjin City [19JCZDJC32400, 18JCQNJC75900]
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A novel mitochondria-targeted fluorescent probe MXSO based on a fluorescent rotatable xanthene-hemicyanine dyad for the detection of viscosity has been successfully designed and synthesized. The probe is able to permeate cell membranes and accumulate in the mitochondria, which is convenient to use for monitoring the changes of mitochondrial viscosity in the living cell.
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