Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 52, Issue 7, Pages 768-775Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmaa045
Keywords
IL-33; glucose; adipose; metabolism
Categories
Funding
- Young Scientist Foundation of NSFC [31822017]
- Zhejiang Provincial Natural Science Foundation of China [LR19C080001]
- National Natural Science Foundation of China [81572651, 81771675]
- Fundamental Research Funds for the Central Universities
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Interleukin-33 (IL-33) is produced by various types of cells under physical or pathological conditions. As a multifunctional partner in health and disease, current evidence reveals that IL-33 also participates in several metabolic processes. IL-33 has been proven to contribute to regulating the activity of ST2(+) group 2 innate lymphoid cells and regulatory T cells in adipose, which leads to the shift of insulin sensitivity and glucose clearance in glucose metabolism, thermogenesis, and adipocyte beiging in adipose metabolism. In this review, we briefly summarize the biological characteristics of Il-33 and discuss its regulatory function in glucose and adipose metabolism. By clarifying the underlying mechanism of IL-33, we highlight the crosstalk between immune response and metabolic processes mediated by IL-33.
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