Journal
INDIAN JOURNAL OF MICROBIOLOGY
Volume 58, Issue 1, Pages 114-117Publisher
SPRINGER
DOI: 10.1007/s12088-017-0694-9
Keywords
Acute hepatopancreatic necrosis disease (AHPND); Vibrio parahaemolyticus; Phage prophylaxis; Phage therapy
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014R1A2A1A11050093, 2017R1C1B2004616]
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Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus has been one of the most problematic diseases in marine shrimp aquaculture throughout Southeast Asia and Latin America. To evaluate the effectiveness of a bacteriophage (phage) treatment for AHPND, a series of bioassays were carried out in a marine shrimp (Penaeus vannamei) model using an AHPND-V. parahaemolyticus strain that is highly pathogenic to shrimp. We monitored the mortality and histopathological changes during phage treatment. Shrimps treated with phage prophylaxis and phage therapy displayed significant protection from AHPND and survived a lethal bacterial challenge.
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