Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 37, Pages 8546-8557Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb01425g
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Funding
- National Nature Science Foundation of China [51672247]
- ZJU-Hangzhou Global Scientific and Technological Innovation Centre
- '111' Program - Education Ministry of China and State Bureau of Foreign Experts Affairs [B16043]
- Fundamental Research Funds for the Central Universities
- Provincial Key Research Program of Zhejiang Province [2020C04005]
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Amino acids are the fundamental building blocks of proteins in tumor cells. The consumption of amino acid can be an effective approach for destroying the tumor cytoskeleton and malfunctioning of the intracellular metabolic balance. Following this concept, herein, amino acid oxidase (AAO) is delivered by hollow Fe3+/tannic acid nanocapsules (HFe-TA) and incorporated within the cancer cell membrane (M) for the first time for synergistic tumor therapy. In this system (M@AAO@HFe-TA), the intracellularly delivered AAO molecules catalyze the oxidative deamination effectively and consume amino acids significantly. The upregulation of intracellular acid and H(2)O(2)concentration facilitates the HFe-TA mediated Fenton reaction and enhances the induction of cytotoxic degrees OH. With the combined effects, considerablein vitroandin vivotumor inhibition was achieved by M@AAO@Fe-TA due to the activated Bcl-2/Bax/CytC/caspase 3 mitochondrial apoptotic pathway. This study offers an alternative therapeutic platform, functioning as a biomimetic cascade nanozyme, to enable synergistic starvation and chemodynamic tumor therapy with high efficacy.
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