Journal
SCIENCE
Volume 370, Issue 6514, Pages 327-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abc0033
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Funding
- Human Frontiers of Science Program (HFSP)
- Senri Life Science Foundation
- Kato Memorial Bioscience Foundation
- JSPS KAKENHI [20K15828]
- World Premier International Research Center Initiative (WPI), MEXT, Japan
- Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship [F32DK123939]
- NSF Center for Cellular Construction [DBI-1548297]
- DARPA Engineered Living Materials program
- Howard Hughes Medical Institute
- NIH [R01-DE028496, R35-DE026602]
- Grants-in-Aid for Scientific Research [20K15828] Funding Source: KAKEN
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In metazoan tissues, cells decide their fates by sensing positional information provided by specialized morphogen proteins. To explore what features are sufficient for positional encoding, we asked whether arbitrary molecules (e.g., green fluorescent protein or mCherry) could be converted into synthetic morphogens. Synthetic morphogens expressed from a localized source formed a gradient when trapped by surface-anchoring proteins, and they could be sensed by synthetic receptors. Despite their simplicity, these morphogen systems yielded patterns reminiscent of those observed in vivo. Gradients could be reshaped by altering anchor density or by providing a source of competing inhibitor. Gradient interpretation could be altered by adding feedback loops or morphogen cascades to receiver cell response circuits. Orthogonal cell-cell communication systems provide insight into morphogen evolution and a platform for engineering tissues.
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