Long-term exposure to PM10and NO2in relation to lung function and imaging phenotypes in a COPD cohort

Background Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investigated the influence of long-term exposure to air pollution on lung function and quantitative imaging measurements in a Korean cohort of participants with and without COPD diagnosis. Methods Study participants (N = 457 including 296 COPD cases) were obtained from the COPD in Dusty Areas (CODA) cohort. Annual average concentrations of particulate matter less than or equal to 10 mu m in diameter (PM10) and nitrogen dioxide (NO2) were estimated at the participants' residential addresses using a spatial air pollution prediction model. All the participants underwent volumetric computerized tomography (CT) and spirometry measurements and completed survey questionnaires. We examined the associations of PM(10)and NO(2)with FVC, FEV1, emphysema index, and wall area percent, using linear regression models adjusting for age, gender, education, smoking, height, weight, and COPD medication. Results The age of study participants averaged 71.7 years. An interquartile range difference in annual PM(10)exposure of 4.4 mu g/m(3)was associated with 0.13 L lower FVC (95% confidence interval (CI), - 0.22- -0.05,p = 0.003). Emphysema index (mean = 6.36) was higher by 1.13 (95% CI, 0.25-2.02,p = 0.012) and wall area percent (mean = 68.8) was higher by 1.04 (95% CI, 0.27-1.80,p = 0.008). Associations with imaging phenotypes were not observed with NO2. Conclusions Long-term exposure to PM(10)correlated with both lung function and COPD-relevant imaging phenotypes in a Korean cohort.