4.3 Article

Gating and calcium-sensing mechanisms of TRPA1 channels revealed

Journal

CELL CALCIUM
Volume 91, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102278

Keywords

TRP; Channel; Calcium; Mustard; Sensory; Pain

Categories

Funding

  1. National Institutes of Health [R01GM126581]
  2. FONDECYT grant [1191868]
  3. Millennium Nucleus of Ion Channels Associated Diseases (MiNICAD), Iniciativa Cientifica Milenio, Ministry of Economy, Development and Tourism, Chile

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Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca2+ modulatory site that is likely conserved among several TRP subgroups.

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