Journal
IMMUNOLOGY LETTERS
Volume 188, Issue -, Pages 108-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2017.07.003
Keywords
Myeloid-derived suppressor cells; MDSCs; B cells
Categories
Funding
- German Research Foundation (Deutsche Forschungsgemeinschaft, Emmy Noether Programme) [HA 5274/3-1, CRC/SFB685]
- CNPq (National Council for Scientific and Technological Development-Brazil)
- Ministry of Science, Research and Arts of Baden Wurttemberg [Az.: SI-BW 01222-91]
- Deutsche Forschungsgemeinschaft DFG (German Research Foundation) [Az.:INST 2388/33-1]
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Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1, nitric oxide (NO), reactive oxygen species (ROS) as well as B-cell death. Collectively, our studies provide novel evidence that human MDSCs modulate B cells, which could have future implications for immunotherapy approaches.
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