Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 37, Issue 1, Pages 141-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2016.08.014
Keywords
Contact; Dermatitis; Allergen; T cell; Patch; Work related
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Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants. Targeted therapies are lacking.
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