Journal
IMMUNOLOGICAL REVIEWS
Volume 278, Issue 1, Pages 185-191Publisher
WILEY
DOI: 10.1111/imr.12558
Keywords
allergic diseases; cell source; cell target; cytokines; IL-25; IL-25-mediated diseases
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Funding
- Ministry of Science and Technology of China
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IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions. Our knowledge on IL-25 will pave the pathway for targeting this cytokine in inflammatory diseases.
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