Journal
IMMUNOLOGICAL REVIEWS
Volume 275, Issue 1, Pages 161-182Publisher
WILEY
DOI: 10.1111/imr.12481
Keywords
Env trimers; HIV-1 vaccines; neutralizing antibodies
Categories
Funding
- NIH [P01 AI110657]
- Collaboration for AIDS Vaccine Discovery (CAVD) grants from the Bill and Melinda Gates Foundation [OPP1111923, OPP1132237]
- European Union's Horizon research and innovation programme [681137]
- Aids Fonds Netherlands [2011032, 2012041, 2016019]
- Vidi grant from the Netherlands Organization for Scientific Research [917.11.314]
- Starting Investigator Grant from the European Research Council [ERC-StG-2011-280829-SHEV]
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We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.
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