New findings in the roles of Cyclin-dependent Kinase inhibitors 2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 G/C and rs4977574 A/G variants on the risk to coronary heart disease

The relationship between Cyclin-Dependent Kinase Inhibitors 2B Antisense RNA 1 (CDKN2B-AS1) variants rs1333049 G/C and rs4977574 A/G and the risk of coronary heart disease is unclear. We conducted an update analysis incorporating odds ratios and 95% confidence intervals to assess the correlation. Furthermore, we usedin silicoanalysis to investigate the genes and proteins that interact with CDKN2B. Fifty case-control studies with a sample size of 35,915 cases and 48,873 controls were involved. We revealed that the rs1333049 C allele could increase the risk of coronary heart disease in the overall analysis (allele comparison, OR = 1.13, 95%CI = 1.05-1.21,P= 0.001; homozygous contrast, OR = 1.29, 95%CI = 1.11-1.49,P= 0.001; dominant comparison, OR = 1.14, 95%CI = 1.03-1.27,P= 0.011; recessive comparison, OR = 1.21, 95%CI = 1.10-1.34,P< 0.001). In subgroup analysis, positive correlations were detected in studies involving West and East Asians and in population-based control studies. The rs4977574 G allele was also a risk factor for coronary heart disease (allelic comparison,P= 0.001; heterozygous comparison,P= 0.003; homozygous comparison,P< 0.001; dominant comparison,P= 0.001). These results indicate correlation ofCDKN2B-AS1rs1333049 G/C and rs4977574 A/G variants may be correlated with the risk of coronary heart disease.