Related references
Note: Only part of the references are listed.Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications
Michael J. Ombrello et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death
Akhouri Kishore Raghawan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Hero turned villain: NLRP3 inflammasomeinduced inflammation during influenza A virus infection
James D. H. Ong et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2017)
Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients
Karen Put et al.
ARTHRITIS & RHEUMATOLOGY (2017)
Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition
Scott W. Canna et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
Viola Neudecker et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Inflammasomes in the lung
James W. Pinkerton et al.
MOLECULAR IMMUNOLOGY (2017)
Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis
Vanessa Buatois et al.
TRANSLATIONAL RESEARCH (2017)
NLRP6: A Multifaceted Innate Immune Sensor
Maayan Levy et al.
TRENDS IN IMMUNOLOGY (2017)
Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker
Tsai-Ling Liao et al.
SCIENTIFIC REPORTS (2017)
Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis
Christoph Kessel et al.
ARTHRITIS & RHEUMATOLOGY (2017)
The immunopathology of sepsis and potential therapeutic targets
Tom van der Poll et al.
NATURE REVIEWS IMMUNOLOGY (2017)
Acute Lung Injury A Clinical and Molecular Review
Yasmeen Butt et al.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2016)
Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis
Rupali Das et al.
BLOOD (2016)
The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Veronica M. Ringel-Scaia et al.
CRITICAL REVIEWS IN IMMUNOLOGY (2016)
Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis
Ellen Brisse et al.
JOURNAL OF IMMUNOLOGY (2016)
Macrophage activation syndrome in the era of biologic therapy
Alexei A. Grom et al.
NATURE REVIEWS RHEUMATOLOGY (2016)
A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus
Elizabeth A. McKie et al.
PLOS ONE (2016)
Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18
James Lawrence Wynn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Elevated serum levels of free interleukin-18 in adult-onset Still's disease
Charlotte Girard et al.
RHEUMATOLOGY (2016)
Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition
Michelle D. Tate et al.
SCIENTIFIC REPORTS (2016)
Interleukin-18: The Bouncer at the Mucosal Bar
Timothy W. Hand
CELL (2015)
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling
Maayan Levy et al.
CELL (2015)
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Roni Nowarski et al.
CELL (2015)
Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis
Masaki Shimizu et al.
CLINICAL IMMUNOLOGY (2015)
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
Dov B. Ballak et al.
CYTOKINE (2015)
Pyroptotic cell death defends against intracellular pathogens
Ine Jorgensen et al.
IMMUNOLOGICAL REVIEWS (2015)
Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency
Bianca Tesi et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
O. J. Harrison et al.
MUCOSAL IMMUNOLOGY (2015)
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Claudia A. Nold-Petry et al.
NATURE IMMUNOLOGY (2015)
Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
Suzhao Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-gamma
Karen Put et al.
RHEUMATOLOGY (2015)
The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
Jing Guo et al.
SCIENTIFIC REPORTS (2015)
Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome
Loredana Cifaldi et al.
ARTHRITIS & RHEUMATOLOGY (2015)
Clinical, Virological and Immunological Features from Patients Infected with Re-Emergent Avian-Origin Human H7N9 Influenza Disease of Varying Severity in Guangdong Province
Zi Feng Yang et al.
PLOS ONE (2015)
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
Stefano Toldo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)
Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock
Tom Vanden Berghe et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma
Hanako Oda et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2014)
Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells.
Silvia Alboni et al.
BRAIN BEHAVIOR AND IMMUNITY (2014)
NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion
Marta Wlodarska et al.
CELL (2014)
Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency
Taizo Wada et al.
CYTOKINE (2014)
Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice
Marina Bersudsky et al.
GUT (2014)
Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1
Yun-peng Luo et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2014)
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
Neil Romberg et al.
NATURE GENETICS (2014)
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Scott W. Canna et al.
NATURE GENETICS (2014)
Clinical Manifestations of Adult-Onset Still's Disease Presenting With Erosive Arthritis: Association With Low Levels of Ferritin and Interleukin-18
Hisae Ichida et al.
ARTHRITIS CARE & RESEARCH (2014)
Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis
Kenneth M. Kaufman et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Systemic Juvenile Idiopathic Arthritis-like Syndrome in Mice Following Stimulation of the Immune System With Freund's Complete Adjuvant Regulation by Interferon-γ
Anneleen Avau et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Role of IL-18 in Second-Hand Smoke-Induced Emphysema
Adelheid Kratzer et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Interferon-γ Mediates Anemia but Is Dispensable for Fulminant Toll-like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis in Mice
Scott W. Canna et al.
ARTHRITIS AND RHEUMATISM (2013)
Anti-IL-12/23 in Crohn's Disease: Bench and Bedside
Lukas Niederreiter et al.
CURRENT DRUG TARGETS (2013)
Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles
Masaki Shimizu et al.
CYTOKINE (2013)
Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79 years: A nested case-control study
Barbara J. Jefferis et al.
CYTOKINE (2013)
Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice
Birgitte Lindegaard et al.
DIABETES (2013)
First-line therapy in adult Crohn's disease: who should receive anti-TNF agents?
Laurent Peyrin-Biroulet et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)
IL-18 Induces Airway Hyperresponsiveness and Pulmonary Inflammation via CD4+ T Cell and IL-13
Masanori Sawada et al.
PLOS ONE (2013)
Interleukin-18, more than a Th1 cytokine
Daniela Novick et al.
SEMINARS IN IMMUNOLOGY (2013)
Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease
Julie L. McAuley et al.
PLOS PATHOGENS (2013)
Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice
Birthe Jessen et al.
FRONTIERS IN IMMUNOLOGY (2013)
Opposing functions of classic and novel IL-1 family members in gut health and disease
Loris R. Lopetuso et al.
FRONTIERS IN IMMUNOLOGY (2013)
Interleukin-18 and IL-18 binding protein
Charles A. Dinarello et al.
FRONTIERS IN IMMUNOLOGY (2013)
IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13
Min-Jong Kang et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury
Tamas Dolinay et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
Familial and Acquired Hemophagocytic Lymphohistiocytosis
G. E. Janka
ANNUAL REVIEW OF MEDICINE, VOL 63 (2012)
Amplification of the response to toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: Implication for the pathogenesis of macrophage activation syndrome
Raffaele Strippoli et al.
ARTHRITIS AND RHEUMATISM (2012)
The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness
Keith A. Sikora et al.
ARTHRITIS AND RHEUMATISM (2012)
Systemic juvenile idiopathic arthritis
Alberto Martini
AUTOIMMUNITY REVIEWS (2012)
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
Mathias Gelderblom et al.
BLOOD (2012)
Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis
Lina Badimon
CARDIOVASCULAR RESEARCH (2012)
Increased Expression of Interleukin-18 and its Receptor in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease
Jianmiao Wang et al.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2012)
Compensated inflammation in systemic juvenile idiopathic arthritis: Role of alternatively activated macrophages
Masaki Shimizu et al.
CYTOKINE (2012)
New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation
Giorgos Bamias et al.
CYTOKINE (2012)
M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages
Francesca Bellora et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome
Hideyuki Makabe et al.
JOURNAL OF ANESTHESIA (2012)
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection
Mathias Oertli et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1β and IL-18
Iris Hitzler et al.
JOURNAL OF IMMUNOLOGY (2012)
Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
Lukas Bossaller et al.
JOURNAL OF IMMUNOLOGY (2012)
Natural Killer Cell Cytolytic Function in Korean Patients with Adult-onset Still's Disease
Jeong Ha Park et al.
JOURNAL OF RHEUMATOLOGY (2012)
Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis
Fabrizio De Benedetti et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein
Laura Chiossone et al.
FRONTIERS IN IMMUNOLOGY (2012)
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Eran Elinav et al.
CELL (2011)
Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma
H. Imaoka et al.
EUROPEAN RESPIRATORY JOURNAL (2011)
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
Edward M. Behrens et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki et al.
NATURE (2011)
Interleukin 37 expression protects mice from colitis
Eoin N. McNamee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The role of interleukin-18 in the metabolic syndrome
Marius Troseid et al.
CARDIOVASCULAR DIABETOLOGY (2010)
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
Christian Bauer et al.
GUT (2010)
Interleukin-18 in Intestinal Inflammation: Friend and Foe?
Britta Siegmund
IMMUNITY (2010)
The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis
Md. Hasan Zaki et al.
IMMUNITY (2010)
Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases
Jeremy Dupaul-Chicoine et al.
IMMUNITY (2010)
Granzyme B is a novel interleukin-18 converting enzyme
Youichi Omoto et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2010)
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell et al.
NATURE (2010)
IL-37 is a fundamental inhibitor of innate immunity
Marcel F. Nold et al.
NATURE IMMUNOLOGY (2010)
Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis
Claudia A. Nold-Petry et al.
PLOS ONE (2010)
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules
Genevieve de Saint Basile et al.
NATURE REVIEWS IMMUNOLOGY (2010)
IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice
Qianli Yu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
A Functional Polymorphism in IL-18 Is Associated with Severity of Bronchial Asthma
Michishige Harada et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Defective Phosphorylation of Interleukin-18 Receptor β Causes Impaired Natural Killer Cell Function in Systemic-Onset Juvenile Idiopathic Arthritis
Wilco de Jager et al.
ARTHRITIS AND RHEUMATISM (2009)
The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
Irving C. Allen et al.
IMMUNITY (2009)
The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Paul G. Thomas et al.
IMMUNITY (2009)
Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity
Caroline E. Sutton et al.
IMMUNITY (2009)
Increased Cytokine Production in Interleukin-18 Receptor α-deficient Cells Is Associated with Dysregulation of Suppressors of Cytokine Signaling
Claudia A. Nold-Petry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury
Kaliyamurthi Venkatachalam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
Alexandra-Chloe Villani et al.
NATURE GENETICS (2009)
IL-18 gene polymorphism and metabolic syndrome
I. Presta et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2009)
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction
Meijing Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP
Alexandra Zhernakova et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
Marco Gattorno et al.
ARTHRITIS AND RHEUMATISM (2008)
Interleukin 18 receptor 1 gene polymorphisms are associated with asthma
Guohua Zhu et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2008)
Interleukin-18 production and pulmonary function in COPID
H. Imaoka et al.
EUROPEAN RESPIRATORY JOURNAL (2008)
Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease
Steven T. Leach et al.
INFLAMMATORY BOWEL DISEASES (2008)
Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus
G. R. C. Zilverschoon et al.
INTERNATIONAL JOURNAL OF OBESITY (2008)
Prointerleukin-18 Is Activated by Meprin β in Vitro and in Vivo in Intestinal Inflammation
Sanjita Banerjee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The effect of daily administration of IL-18 on cardiac structure and function
A. Platis et al.
PERFUSION-UK (2008)
Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still's Disease
Der-Yuan Chen et al.
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH (2007)
Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
Ndate Fall et al.
ARTHRITIS AND RHEUMATISM (2007)
Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss
Jens M. Bruun et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2007)
Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis results from the Dallas heart study
Andreas Zirlik et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Pulmonary inflammation and emphysema - Role of the Cytokines IL-18 and IL-13
Tomoaki Hoshino et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Eric P. Zorriila et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Specific gene expression profiles in systemic juvenile idiopathic arthritis
Emma Mary Ogilvie et al.
ARTHRITIS AND RHEUMATISM (2007)
Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
Mohammad A. Amin et al.
ARTHRITIS AND RHEUMATISM (2007)
IL-18 is induced and IL-18 receptor α plays a critical role in the pathogenesis of cigarette emphysema and inflammation
Min-Jong Kang et al.
JOURNAL OF IMMUNOLOGY (2007)
IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells
Alice E. Denton et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2007)
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
Darwyn Kobasa et al.
NATURE (2007)
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment
Youichi Omoto et al.
JOURNAL OF IMMUNOLOGY (2006)
Interleukin-18 levels are not associated with subclinical carotid atherosclerosis in a community population - The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Caroline M. L. Chapman et al.
ATHEROSCLEROSIS (2006)
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
Eli C. Lewis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Perforin and granzymes have distinct roles in defensive immunity and immunopathology
Serani L. H. van Dommelen et al.
IMMUNITY (2006)
Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related-to severity of coronary atherosclerosis independently of C-reactive protein and IL-6
Johannes Hulthe et al.
ATHEROSCLEROSIS (2006)
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
MG Netea et al.
NATURE MEDICINE (2006)
Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity
Gerit-Holger Schernthaner et al.
OBESITY SURGERY (2006)
Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population
T Takagawa et al.
INFLAMMATORY BOWEL DISEASES (2005)
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome
K Mazodier et al.
BLOOD (2005)
Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans
CP Fischer et al.
CLINICAL IMMUNOLOGY (2005)
Diagnosis and management of the metabolic syndrome - An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
SM Grundy et al.
CIRCULATION (2005)
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
PR Woldbæk et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
T Skurk et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2005)
Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance
J Hung et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
V Pascual et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes
B Chandrasekar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
An interferon-γ-related cytokine storm in SARS patients
KJ Huang et al.
JOURNAL OF MEDICAL VIROLOGY (2005)
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
J Villanueva et al.
ARTHRITIS RESEARCH & THERAPY (2005)
Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus
KF Van der Sluijs et al.
IMMUNOLOGY (2005)
Re-emergence of fatal human influenza A subtype H5N1 disease
JSM Peiris et al.
LANCET (2004)
Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity
BX Liu et al.
JOURNAL OF GENERAL VIROLOGY (2004)
An animal model of hemophagocytic lymphohistiocytosis (HLH):: CD8+ T cells and interferon gamma are essential for the disorder
MB Jordan et al.
BLOOD (2004)
The nature of small-airway obstruction in chronic obstructive pulmonary disease
JC Hogg et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Differences in signaling pathways by IL-1β and IL-18
JK Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients - A postmortem clinicopathologic analysis
R Strauss et al.
CRITICAL CARE MEDICINE (2004)
Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome
N Maeno et al.
ARTHRITIS AND RHEUMATISM (2004)
Interleukin-18 and the risk of coronary heart disease in European men -: The Prospective Epidemiological Study of Myocardial Infarction (PRIME)
S Blankenberg et al.
CIRCULATION (2003)
Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy
DG Remick et al.
CRITICAL CARE MEDICINE (2003)
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
T Ishikura et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2003)
Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction
PR Woldbaek et al.
CARDIOVASCULAR RESEARCH (2003)
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
R Elhage et al.
CARDIOVASCULAR RESEARCH (2003)
Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
AA Grom et al.
JOURNAL OF PEDIATRICS (2003)
Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein
NK Banda et al.
JOURNAL OF IMMUNOLOGY (2003)
The promoter of IL-18 binding protein:: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β
V Hurgin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia
VD Joshi et al.
INFECTION AND IMMUNITY (2002)
Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease
O Ludwiczek et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2002)
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
P Bufler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: High serum IL-18 as an early predictive indicator of lethal outcome
K Emmanuilidis et al.
SHOCK (2002)
Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al
N Maeno et al.
ARTHRITIS AND RHEUMATISM (2002)
IL-18 levels and the outcome of innate immune response to lipopolysaccharide: Importance of a positive feedback loop with caspase-1 in IL-18 expression
VD Joshi et al.
JOURNAL OF IMMUNOLOGY (2002)
Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina
S Blankenberg et al.
CIRCULATION (2002)
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
PV Sivakumar et al.
GUT (2002)
Interleukin-18 enhances atherosclerosis in apolipoprotein E-/- mice through release of interferon-γ
SC Whitman et al.
CIRCULATION RESEARCH (2002)
Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages:: Implications for atherogenesis
N Gerdes et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Effect of interleukin-18 on mouse core body temperature
S Gatti et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2002)
Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice
T Ten Hove et al.
GASTROENTEROLOGY (2001)
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells
S Sugawara et al.
JOURNAL OF IMMUNOLOGY (2001)
IL-1β-converting enzyme (caspase-1) in intestinal inflammation
B Siegmund et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A novel role for interleukin-18 in adhesion molecule induction through NFκB and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways
JCM Morel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability
Z Mallat et al.
CIRCULATION (2001)
Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFκB activation
JCM Morel et al.
LABORATORY INVESTIGATION (2001)
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
T Kanai et al.
GASTROENTEROLOGY (2001)
Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability
Z Mallat et al.
CIRCULATION RESEARCH (2001)
A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18
D Novick et al.
CYTOKINE (2001)
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β
BJ Pomerantz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
IL-18 might reflect disease activity in mild and moderate asthma exacerbation
H Tanaka et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)
Interleukin 18 in acute myocardial infarction
Y Seta et al.
HEART (2000)
IL-18 induction of IgE:: dependence on CD4+ T cells, IL-4 and STAT6
T Yoshimoto et al.
NATURE IMMUNOLOGY (2000)
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-γ production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21
U Kalina et al.
JOURNAL OF IMMUNOLOGY (2000)
Pathophysiological roles of interleukin-18 in inflammatory liver diseases
H Tsutsui et al.
IMMUNOLOGICAL REVIEWS (2000)
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
SH Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Interferon-γ mediates gene expression of IL-18 binding protein in nonleukocytic cells
H Mühl et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
F Vidal-Vanaclocha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
MG Netea et al.
JOURNAL OF IMMUNOLOGY (2000)
Share Paper
