Journal
IMMUNOLOGICAL REVIEWS
Volume 281, Issue 1, Pages 88-98Publisher
WILEY
DOI: 10.1111/imr.12608
Keywords
glycolysis; inflammasome; inflammation; Krebs cycle; metabolism; NLRP3
Categories
Funding
- Science Foundation Ireland
Ask authors/readers for more resources
A shift in our understanding of macrophage biology has come about as a result of recent discoveries in the area of metabolic reprogramming of macrophages. The NLRP3 inflammasome drives the activation of caspase-1, leading to the production of IL-1 beta, IL-18, and a type of cell death termed pyroptosis. The NLRP3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. The NLRP3 inflammasome has also been shown to be regulated by mitochondrial reactive oxygen species and components of glycolysis, such as Hexokinase. Here, we review these findings and discuss their importance for inflammation and furthermore discuss potential therapeutic benefits of targeting NLRP3.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available