Journal
IMMUNITY
Volume 46, Issue 2, Pages 287-300Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2017.01.009
Keywords
-
Categories
Funding
- Novartis
- Swedish Research Council
- Ragnar Soderberg Stiftelse
- Svenska Lakaresallskapet
- Stockholm County Council
- Psoriasisfonden
- Hudfonden
- European Research Council under the European Union [311335]
- Swedish Cancer Foundation
- Swedish Foundation for Strategic Research
- Stockholm City Council
- Karolinska Institutet Center for Innovative Medicine
- Wallenberg Foundation
- European Research Council (ERC) [311335] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8(+) Trm cells on a compartmental and functional basis. In human skin epithelia, CD8(+)CD49a(+) Trm cells produced interferon-g, whereas CD8(+)CD49a(-) Trm cells produced interleukin-17 (IL-17). In addition, CD8(+)CD49a(+) Trm cells from healthy skin rapidly induced the expression of the effector molecules perforin and granzyme B when stimulated with IL-15, thereby promoting a strong cytotoxic response. In skin from patients with vitiligo, where melanocytes are eradicated locally, CD8(+)CD49a(+) Trm cells that constitutively expressed perforin and granzyme B accumulated both in the epidermis and dermis. Conversely, CD8(+)CD49a(-) Trm cells from psoriasis lesions predominantly generated IL-17 responses that promote local inflammation in this skin disease. Overall, CD49a expression delineates CD8(+) Trm cell specialization in human epithelial barriers and correlates with the effector cell balance found in distinct inflammatory skin diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available