Journal
IMMUNITY
Volume 47, Issue 2, Pages 224-233Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2017.07.009
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Funding
- Rockefeller University
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [P01AI100148, U19AI111825, U19AI109946]
- National Cancer Institute [R35CA196620, P01CA190174]
- Bill & Melinda Gates Foundation [OPP1124068]
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Through specific interactions with distinct types of Fc gamma receptors (Fc gamma Rs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses. Recent studies indicate that IgG Fc-Fc gamma R interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective Fc gamma R expression on immune cells on the other, which together determine the capacity of IgG to interact in a cell-type-specific manner with specific members of the Fc gamma R family. Here, we present a framework that synthesizes the current understanding of the contribution of Fc gamma R pathways to the induction and regulation of antibody and T cell responses. Within this context, we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomodulatory properties of Fc-Fc gamma R interactions.
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