Journal
IMMUNITY
Volume 47, Issue 2, Pages 363-+Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2017.07.016
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Funding
- U.S. National Cancer Institute [CA141975]
- Cancer Prevention and Research Institute of Texas [RR150072]
- Ludwig Foundation for Cancer Research
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Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclear. Here we have shown that CD47-signal regulatory protein alpha (SIRP alpha) axis dictates the fate of ingested DNA in DCs for immune evasion. Although macrophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRP alpha with CD47 preferentially occurred in dendritic cells (DCs) but not in macrophages. Mechanistically, CD47 blockade enabled the activation of NADPH oxidase NOX2 in DCs, which in turn inhibited phagosomal acidification and reduced the degradation of tumor mitochondrial DNA (mtDNA) in DCs. mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contributing to type I interferon (IFN) production and antitumor adaptive immunity. Thus, our findings have demonstrated how tumor cells inhibit innate sensing in DCs and suggested that the CD47-SIRP alpha axis is critical for DC-driven antitumor immunity.
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