Journal
IMMUNITY
Volume 47, Issue 2, Pages 211-214Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2017.07.024
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Funding
- NIH [AI107027, CA014195]
- Nomis Foundation
- Leona M. and Harry B. Helmsley Charitable Trust
- CCFA [402451]
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Hayatsu et al. (2017) reveal that a FOXP3 mutant found in some patients afflicted with the autoimmune disease IPEX has broadened DNA-recognition specificity, directly repressing the expression of the gene encoding the transcription factor Batf. Their findings identify Batf as critical to tissue regulatory T cell function and suggest that polymorphisms that impact FOXP3 DNA-binding specificity may contribute susceptibility to autoimmune disease.
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