4.8 Editorial Material

RSV Takes Control of Neonatal Breg Cells: Two Hands on the Wheel

Journal

IMMUNITY
Volume 46, Issue 2, Pages 171-173

Publisher

CELL PRESS
DOI: 10.1016/j.immuni.2017.01.011

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Funding

  1. Imperial's Health Protection Research Unit (HPRU) in Respiratory Infection
  2. Imperial Biomedical Research Centre (BRC) at Imperial College Healthcare NHS Trust [IS-BRC-1215-20013]
  3. Wellcome Trust [P57603/4]
  4. Medical Research Council, UK [MR/R502121/1]
  5. [602525]
  6. Asthma UK [MRC-Asthma UK Centre, MRC-AsthmaUKCentre] Funding Source: researchfish
  7. Medical Research Council [G1000758, MR/R502121/1] Funding Source: researchfish
  8. National Institute for Health Research [NF-SI-0513-10150] Funding Source: researchfish
  9. MRC [MR/R502121/1] Funding Source: UKRI

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The viral attachment protein of RSV has many surprising features, especially its mimicry of fractalkine (CX3CL1). Zhivaki et al. (2017) now show that, in addition to using this homology to attach to ciliated cells, it activates human neonatal regulatory B cells, thereby inhibiting immunological responses.

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