Journal
CURRENT APPLIED PHYSICS
Volume 15, Issue 8, Pages 870-876Publisher
ELSEVIER
DOI: 10.1016/j.cap.2015.03.023
Keywords
Porous silicon microcavity; Au nanoparticle; Reflectance spectrum; Blue shift; DNA biosensor
Funding
- National Science Foundation of China [61265009, 11264083]
- Foundation of Xinjiang Education [XJEDU2013S04]
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A technique is demonstrated to detect DNA hybridization based on surface layer of Au/porous silicon microcavity (Au/PSM) substrate for very small amount of biomolecules. Simulations show that the increase of effective refractive index for the first layer of PSM will cause a blue shift for its reflectance spectrum, and the blue shift becomes less with the increase of refractive index for one more layers. In experiments, such a blue shift of reflectance spectrum of PSM comes from the increase of refractive index by DNA hybridization on the surface. The detection limit of Au/PSM biosensor is 15.15 nM for 19-base pair DNA, which is comparable to that of reported biosensors based on porous silicon (PS). Therefore such an Au/PSM could be very useful to develop simple, rapid and sensitive optical biosensors when the amount of target is very small. (C) 2015 Published by Elsevier B.V.
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