Journal
JOURNAL OF TOXICOLOGICAL SCIENCES
Volume 45, Issue 8, Pages 411-422Publisher
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.45.411
Keywords
La(2)O(3 )nanoparticles; Reproductive toxicity; Inflammation; BTB; Gene-expression
Categories
Funding
- National Natural Science Foundation of China [81302323]
- Natural Science Foundation of Hebei Province of China [C2019209478]
- Key Projects of Hebei Province [ZD2016007]
- PhD Research Startup Foundation of North China University of Science and Technology
Ask authors/readers for more resources
Lanthanum oxide (La2O3) nanoparticles (NPs) have been widely used in photoelectric and catalytic applications. However, their exposure and reproductive toxicity is unknown. In this study, the effect of the intragastric administration of two different-sized La2O3 particles in the testes of mice for 60 days was investigated. Although the body weight of mice treated or not treated with La2O3 NPs was not different and Lap, NPs were distributed in the organs including the testis. liver, kidney, spleen, heart and brain. Lap, NPs accumulate more than micro-sized La2O3 (MPs) in mice testes. The histopathological evaluation showed that moderate reproductive toxicity induced by La2O3 NPs in the testicle tissues. Furthermore, increased MDA. 8-OHdG levels and decreased SOD activities were detected in the Lap, NP-treated groups. Moreover, qRT-PCR and western blotting data indicated that Lap, NPs affecting the blood-testis barrier (BTB)-related genes in mice testes. Taken together, these findings suggested that Lap, NPs activated inflammation responses and cross the BTB in the murine testes. This study provided useful information for risk analysis and regulation of La2O3 NPs by administrative agencies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available