Journal
ELIFE
Volume 9, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.58533
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Funding
- European Commission AUREATE
- Biotechnology and Biological Sciences Research Council [BB/L003023/1, BB/N005279/1, BB/N00194X/1, BB/P02601X/1]
- Japan Society for the Promotion of Science [JP19H05676]
- Agence Nationale de la Recherche EpiGen
- BBSRC [BB/L003023/1, BB/S020934/1, BB/P02601X/1, BB/N00194X/1, BB/N005279/1] Funding Source: UKRI
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Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.
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