Journal
VETERINARY RESEARCH
Volume 51, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13567-020-00850-5
Keywords
adaptive immunity; gene co-expression network; innate immunity; integrated transcriptomes; porcine reproductive and respiratory syndrome virus
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Funding
- National Research Foundation of Korea [NRF-2018R1A6A1A03025159]
- Rural Development Administration of Korea [PJ01181602]
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Porcine reproductive and respiratory syndrome virus (PRRSV) infection is the most important viral disease causing severe economic losses in the swine industry. However, mechanisms underlying gene expression control in immunity-responsible tissues at different time points during PRRSV infection are poorly understood. We constructed an integrated gene co-expression network and identified tissue- and time-dependent biological mechanisms of PRRSV infection through bioinformatics analysis using three tissues (lungs, bronchial lymph nodes [BLNs], and tonsils) via RNA-Seq. Three groups with specific expression patterns (i.e., the 3-dpi, lung, and BLN groups) were discovered. The 3 dpi-specific group showed antiviral and innate-immune signalling similar to the case for influenza A infection. Moreover, we observed adaptive immune responses in the lung-specific group based on various cytokines, while the BLN-specific group showed down-regulated AMPK signalling related to viral replication. Our study may provide comprehensive insights into PRRSV infection, as well as useful information for vaccine development.
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