Journal
NANOSCALE
Volume 12, Issue 38, Pages 19833-19843Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr04682e
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Funding
- State Commission of Science & Technology of China [2016YFC0104100]
- Jiangsu Province Science & Technology Department [BE2018618]
- Nanjing Medical Science and Technique Development Foundation [QRX17174]
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Cancer-associated fibroblasts (CAFs) play a critical role in the onset and progression of malignancies, such as oral squamous cell carcinoma (OSCC), making CAFs a promising druggable target. In this study, gold nanoparticles (GNPs) exhibited unprecedented size dependent anti-CAF potential, wherein the smallest GNPs outperformed their larger counterparts. Specifically, a subset of proteins and cytokines that is responsible for the invasive outgrowth of OSCC cells was found to decrease post exposure of OSCC patient-derived CAFs to GNPs. Moreover, the administration of GNPs (3 nm in diameter) could effectively abrogate the growth of OSCC tumorsin vivo, offering a novel means to manage OSCC in the clinic. Besides targeting cancer cells, our results collectively verify the feasibility of blocking dominant cells in the microenvironment to eradicate tumors, shedding light on the future design of nanomedicines.
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