Journal
NANOSCALE
Volume 12, Issue 38, Pages 19880-19887Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr01986k
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Funding
- National Science Centre, Poland within the grant Maestro [UMO-2016/22/A/ST4/00017]
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The efficient delivery of drugs to cells depends on their diffusion through the extracellular matrix (ECM) of tissues. Here we present a study on the diffusion of nanoprobes of radius from 1 nm to over 100 nm in the ECM of spheroids of three cell types (HeLa, MCF-7 and fibroblasts). We quantified the nanoparticle transport in the spheroids' proliferating zone. We determined the size-dependent viscosity of the ECM. We revealed that nanoobjects up to 10 nm in radius exhibited unobstructed diffusion in the ECM, regardless of the spheroid type. The presented length-scale dependent viscosity profiles for spheroids pave the way for advanced modelling of drug administration through tissues.
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